Understand or prevent a condition.
The redesigned shot didn't lose a step. Moderna's next-generation COVID vaccine, built around one-fifth the dose of the original, protected people against symptomatic infection just as well as the formula the world already knows, in a head-to-head trial of 11,454… Read More →
Anyone who's quit cigarettes and drifted back knows the arithmetic of willpower alone. A trial of 792 American smokers suggests the odds shift substantially with a pill called cytisinicline: 30.3% of those who took it for 12 weeks weren't smoking… Read More →
Could one steady pill a day carry early Parkinson's disease, before levodopa enters the picture? That was the question behind TEMPO-2, and the answer came back yes. Over 27 weeks, 304 adults in the first years of the disease took… Read More →
The first pill usually works, until it doesn't. Plenty of men taking an alpha-blocker such as tamsulosin for an enlarged prostate still find themselves up twice a night, and the standard next move is a second daily pill. A French… Read More →
An injection given just twice a year prevented nearly every expected HIV infection in an international trial of 3,265 people. Two participants receiving lenacapavir acquired HIV over the follow-up period, an infection rate 96% below what researchers calculated would have… Read More →
Can a daily spoonful of a special sugar stop urinary tract infections from coming back? Researchers in the UK asked exactly that about d-mannose, the supplement stacked on pharmacy shelves for this very purpose, and the answer from the largest… Read More →
For a decade, the most powerful cholesterol drugs have come with a needle attached. If statins didn't get your LDL low enough, the next step up meant injections. That barrier just fell. In a 52-week trial of 2,909 adults with… Read More →
A year and a half ago, this story looked closed. Mavacamten, the first drug of its kind, had just failed in the nonobstructive form of hypertrophic cardiomyopathy, missing both of its main goals in a trial of 580 patients. Its… Read More →
The shingles vaccine asks a fair amount of you: two doses, a sore arm, sometimes a rough day after each one. A natural question follows. How long does what you bought actually last? The final analysis of the vaccine's long-term… Read More →
